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. 2022 May 19;14(5):1094. doi: 10.3390/v14051094

Figure 2.

Figure 2

HIV-1 gRNA interaction with Gag and translocation to assembly sites. (A). Genome recognition occurs in the perinuclear region of the cell. (B). Phase separation of gRNA regulates translocation to virus particle assembly sites. Liquid-liquid phase separation (LLPS), Ribonucleoprotein complex (RNP), Gag nucleocapsid domain (NC). (C). Localization of gRNA to assembly intermediates promotes virus particle assembly. DEAD box Helicase 6 (DDX6), ATP Binding Cassette Subfamily E Member 1 (ABCE1) (D). Retention of gRNA at the plasma membrane is dependent upon interaction with Gag. Created with BioRender.com (accessed 4 May 2022).