Table 1.
Clinical data of patients with positive cultures from pulmonary specimens at the Evandro Chagas National Institute of Infectious Diseases, from 1998 through 2019.
| Case (Year) 1 | Sex | Age | Risk Exposure | Clinical Presentation | Organs and Systems Affected | Comorbidities/ Immunosuppression 2 |
Other Coinfections | Radiological Findings | Pulmonary Positive Culture Specimen | Treatment | Outcome |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
1
(2018) |
Male | 71 | None | Primary pulmonary | Lungs | Alcoholism COPD |
No | Reticulonodular infiltrate; cavitation; fibrosis Unilateral/Multilobar |
Sputum; BAL | ITZ; PSZ | Under treatment |
|
2
(2018) |
Male | 63 | Contact with cat | Disseminated | Lungs, bone | Alcoholism COPD |
No | Cavitation; fibrosis; hilar lymphadenopathy Unilateral/Unilobar |
Sputum; BAL | ITZ; AmB; PSZ | Under treatment |
|
3
(2015) |
Male | 52 | Contact with soil/plants | Disseminated | Skin, lungs, bone | HIV (CD4 = 46 cells/mm3) |
Sepsis caused by Klebsiella | Nodule without cavitation Unilateral/Unilobar |
BAL | ITZ; AmB | Cure |
|
4
(2012) |
Male | 25 | Contact with soil/plants | Disseminated | Skin, lungs, bones, upper airways, eyes | HIV (CD4 = 25 cells/mm3) Alcoholism |
Tuberculosis | Multiple nodules without cavitation Bilateral/Mulilobar |
Sputum; BAL | ITZ; TBF; AmB; PSZ | Death |
|
5
(2015) |
Female | 31 | Contact with diseased cats | Disseminated | Skin, bones | HIV (CD4 = 21 cells/mm3) |
Pulmonary sepsis caused by Acinetobacter Kaposi’s sarcoma |
None | Sputum | ITZ; AmB | Cure |
|
6
(2012) |
Female | 20 | Scratched by diseased cat | Disseminated | Skin, bones, CNS | HIV (CD4 = 42 cells/mm3) |
No | Multiple Nodules without cavitation Bilateral/Multilobar |
Sputum | ITZ; TBF; AmB; PSZ | Death |
|
7
(2007) |
Male | 44 | Contact with soil/plants | Disseminated | Skin, bone, CNS | HIV CD4 = 110 cells/mm3) Alcoholism |
Tuberculosis | Pleural effusion | Sputum | ITZ; AmB | Death |
|
8
(2008) |
Male | 26 | Contact with diseased cat | Disseminated | Skin, upper airways, CNS | HIV (CD4 = 178 cells/mm3) Alcoholism |
No | None | Sputum | ITZ; AmB | Death |
|
9
(2011) |
Male | 36 | Scratched by diseased cat | Disseminated | Skin, bones, upper airways | HIV (CD4 = 66 cells/mm3) |
No | None | Sputum | ITZ; TBF; AmB | Loss of follow-up |
|
10
(2019) |
Male | 46 | Bitten by diseased cat | Disseminated | Skin, bones, upper airways | HIV (CD4 = 35 cells/mm3) Alcoholism |
No | None | Sputum | ITZ; AmB | Cure |
|
11
(2003) |
Male | 18 | Contact with diseased cat and with soil/plants | Disseminated | Skin, bones, upper airways, eyes | Alcoholism | Nocardiosis | Non | Sputum | ITZ; TBF; AmB | Cure |
|
12
(2017) |
Male | 35 | Contact with diseased cat (sneezing) and with soil/plants |
Disseminated | Skin, bones, upper airways, CNS, eyes | HIV (CD4 = 75 cells/mm3) Alcoholism |
Tuberculosis | None | Sputum | ITZ; AmB | Death |
|
13
(2013) |
Male | 43 | Scratched by diseased cat | Disseminated | Skin, bones, upper airways | HIV (CD4 = 35 cells/mm3) Alcoholism |
Tuberculosis | Diffuse reticulonodular infiltrate; calcified nodules, fibrosis | Sputum | ITZ; TBF; AmB; PSZ | Death |
|
14
(2018) |
Female | 20 | Contact with diseased cats | Disseminated | Skin, lungs, bones, upper airways | HIV (CD4 = 56 cells/mm3) Alcoholism |
Pneumocystis pneumonia | Cavitation; reticulonodular infiltrate; consolidation | Sputum | ITZ; AmB; PSZ | Cure |
AmB, Amphotericin B; BAL, Bronchoalveolar lavage; CNS, central nervous system; COPD, chronic obstructive pulmonary disease; HIV, human immunodeficiency virus, ITZ, Itraconazole; TBF, Terbinafine; PSZ, Posaconazole. 1 Year of first isolation of Sporothrix spp. of pulmonary specimen. 2 T CD4+ cell count at the time of collection of pulmonary specimen.