Table 3.
Yield, hydrodynamic radius (RH), polydispersity index (P.I.), encapsulation efficiency (E.E.), drug content (D.C.) and zeta potential (ζ) of VBL-CH/HY NPs at different VBL amounts after resuspension of the lyophilized products. S.D.: standard deviation. See text for details.
| Samples | Yield (%) | RH (nm) ± S.D. | P.I. (%) | E.E. (%) | D.C. (%) | ζ (mV) ± S.D. |
|---|---|---|---|---|---|---|
| Empty NPs | 75.02 ± 16.52 | 110.23 ± 3.15 | 12 ± 3 | -- | -- | −13.51 ± 1.85 |
| 5% VBL-CS/HY NPs | 69.74 ± 12.30 | 115.65 ± 9.87 | 16 ± 1 | 37.78 ± 2.89 | 2.41 ± 5.60 | −12.11 ± 0.87 |
| 15% VBL-CS/HY NPs | 71.00 ± 21.56 | 122.87 ± 10.22 | 15 ± 1 | 56.23 ± 3.54 | 7.45 ± 3.21 | −10.05 ± 0.56 |
| 20% VBL-CS/HY NPs | 55.78 ± 10.02 | 330.75 ± 25.89 | 15 ± 5 | 18.03 ± 5.27 | 5.36 ± 9.35 | −11.34 ± 0.29 |