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Cell immune response in mice by mRNA-RBD vaccines. (a) The proportions of CD3+CD4+ and CD3+CD8+ T cells were tested by flow cytometry. (b) The percentages of IFNγ-producing CD4+ and CD8+ T cells were detected by intracellular cytokine staining. LNP, lipid nanoparticle; RBD, receptor-binding domain. (** p < 0.01; *** p < 0.001).
