Table 3.
Biodistribution of boron concentration after administration of 4-BPA-Fru in melanoma-bearing mice (%ID/g, n = 16).
| Time after Administration (min) | ||||
|---|---|---|---|---|
| 10 (n = 4) |
30 (n = 4) |
60 (n = 4) |
120 (n = 4) |
|
| Plasma | 5.5 ± 0.7 | 3.1 ± 0.2 | 2.7 ± 0.2 | 1.6 ± 0.2 |
| Liver | 7.4 ± 0.7 | 4.2 ± 0.2 | 2.9 ± 0.3 | 2.0 ± 0.1 |
| Kidneys | 16.9 ± 2.5 | 10.8 ± 1.6 | 8.4 ± 3.7 | 4.7 ± 0.6 |
| Pancreas | 44.1 ± 7.0 | 44.8 ± 5.7 | 33.9 ± 6.5 | 12.9 ± 1.4 |
| Brain | 1.3 ± 0.1 | 2.5 ± 0.2 | 3.0 ± 0.3 | 2.2 ± 0.2 |
| Skin | 5.2 ± 0.7 | 4.4 ± 0.5 | 5.0 ± 0.9 | 2.5 ± 0.3 |
| Muscle | 3.1 ± 0.7 | 4.2 ± 0.4 | 4.4 ± 0.3 | 2.8 ± 0.3 |
| B16F10 melanoma | 4.3 ± 1.4 | 6.4 ± 1.0 | 8.6 ± 0.6 | 5.8 ± 0.4 |
| Tumor/Plasma | 0.8 ± 0.3 | 2.1 ± 0.3 | 3.2 ± 0.1 | 3.6 ± 0.4 |