Table 1.
Recommended HIPEC Regimens for Appendiceal and Colorectal Cancers in the US. The most common established regimens across societies are shown and first-line recommendations are bolded. MMC (mitomycin C), PCI (peritoneal carcinomatosis index).
| Primary Malignancy |
Agent | Duration | Dose/ Concentration |
Bidirectional IV Therapy | Ref. |
|---|---|---|---|---|---|
| Appendiceal | MMC | 90 min | 30 mg (0 min) + 10 mg (60 min) | -- | [129,130] |
| 90–120 min | 30 mg/m2 | -- | [129,130] | ||
| MMC + doxorubicin | 90 min | 15 mg/m2, 15 mg/m2 | 5-FU (400 mg/m2) + Leucovorin (20 mg/m2) |
[129,130] | |
| Oxaliplatin | 30 min | 300 mg/m2 | 5-FU (400 mg/m2) + Leucovorin (20 mg/m2) |
[129] | |
| Colorectal | MMC | 90 min | 30 mg (0 min) + 10 mg (60 min) | -- | [130,131,132] |
| 90–110 min | 30 mg/m2 | -- | [130,131,132] | ||
| Oxaliplatin (only with PCI 11–15) |
30 min | 300 mg/m2 | 5-FU (400 mg/m2) + Leucovorin (20 mg/m2) |
[131] |