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. 2022 May 18;11(10):2839. doi: 10.3390/jcm11102839

Table 2.

Summary of studies on the effects of tDCS on Schizophrenia (SCZ).

Subjects tDCS Intervention Brain Region Conclusion Ref.
Adolescent MIS rats Anodal or cathodal; 50 µA; 20 min × 2/day Prefrontal cortex Prevent positive neurological and behavior symptoms of schizophrenia [48]
Patients with refractory auditory verbal hallucinations Anodal and cathodal; 2 mA; 20 min × 2/day Dorsolateral prefrontal cortex (anodal) and temporoparietal junction (cathodal) Significant improvement on AHRS for up to 3 months. [33,49]
SCZ patients18–25 years of age Anodal and cathodal; 2 mA; 20 min × 2/day Dorsolateral pre-frontal cortex (an-odal) and temporo-parietal junction (cathodal) Amelioration of negative symptoms, except passive/apathetic withdrawal and stereotyped thinking, that lasted up to 6 weeks after the end of the trial. [50]
SCZ patients Eight cognitive training sessions (two session/day) combined with anodal, 2 mA, 30 min Dorsolateral pre-frontal cortex tDCS therapy leads to improvements in working memory, and a positive effect on retention of learning [51]

MIS—maternal immune stimulation. AHRS—Auditory Hallucination Rating Scale.