Table 2.

Top 25 metabolites for FEV₁ from adaLASSO analysis, adaLASSO coefficient, and Super and Sub pathways annotated from Metabolon.

Metabolite	adaLASSO β	Super Pathway (Metabolon)	Sub Pathway (Metabolon)
vanillylmandelate (VMA)	−0.5654	Amino Acid	Tyrosine Metabolism
N1-methyladenosine	−0.3571	Nucleotide	Purine Metabolism, Adenine containing
Glutamine	−0.3414	Amino Acid	Glutamate Metabolism
2-hydroxypalmitate	−0.3264	Lipid	Fatty Acid, Monohydroxy
choline phosphate	0.2924	Lipid	Phospholipid Metabolism
1-palmitoyl-2-stearoyl-GPC (16:0/18:0)	0.2912	Lipid	Phosphatidylcholine (PC)
cerotoylcarnitine (C26) *	0.2859	Lipid	Fatty Acid Metabolism (Acyl Carnitine, Long Chain Saturated)
phenylalanine	−0.2675	Amino Acid	Phenylalanine Metabolism
dimethylarginine (SDMA + ADMA)	0.2646	Amino Acid	Urea cycle; Arginine and Proline Metabolism
myo-inositol	0.2568	Lipid	Inositol Metabolism
imidazole lactate	0.2561	Amino Acid	Histidine Metabolism
1-stearoyl-2-arachidonoyl-GPC (18:0/20:4)	−0.2456	Lipid	Phosphatidylcholine (PC)
N-acetylvaline	0.2374	Amino Acid	Leucine, Isoleucine and Valine Metabolism
taurine	−0.2325	Amino Acid	Methionine, Cysteine, SAM, and Taurine Metabolism
sulfate *	0.2325	Xenobiotics	Chemical
3-methyl-2-oxovalerate	−0.2206	Amino Acid	Leucine, Isoleucine, and Valine Metabolism
gamma-glutamylthreonine	0.2162	Peptide	Gamma-glutamyl Amino Acid
proline	0.2127	Amino Acid	Urea cycle; Arginine and Proline Metabolism
mannonate *	−0.2107	Xenobiotics	Food Component/Plant
retinol (vitamin A)	0.2103	Cofactors and Vitamins	Vitamin A Metabolism
sphingomyelin (d18:2/21:0, d16:2/23:0) *	−0.1919	Lipid	Sphingomyelins
N-acetylcarnosine	0.1825	Amino Acid	Histidine Metabolism
3beta-hydroxy-5-cholestenoate	0.1798	Lipid	Sterol
pimelate (C7-DC)	−0.1790	Lipid	Fatty Acid, Dicarboxylate