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. 2022 May 4;10(5):721. doi: 10.3390/vaccines10050721

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Determination of CD8⁺ T cell activation ex vivo after immunization. The expression of three different activation markers, CD69, CD71, and CD25, was evaluated ex vivo in cells from mice immunized with the recombinant BCGs. For rBCG-N-SARS-CoV-2, the activation of CD69 (A), CD71 (B), and CD25 (C) were evaluated in CD8⁺ T cells. For rBCG-N-ANDV, the activation of CD69 (D), CD71 (E), and CD25 (F) were evaluated in CD8⁺ T cells. Data are representative of 3 independent experiments. Each experiment considered a total of three mice per group. Statistical differences were assessed by two-way ANOVA with a post hoc Tukey test. *: p < 0.05; **: p < 0.01; ***: p < 0.001.