Table 1.
Risk of drug-related allergy and anaphylaxis by patients’ characteristics.
| Overall N = 94,073 (%) |
Non-Allergy N = 79,993 (%) |
Allergy N = 13,532 (%) |
Anaphylaxis N = 548 (%) |
Adjusted ROR of Allergy (95% CI) | Adjusted ROR of Anaphylaxis (95% CI) | ||
|---|---|---|---|---|---|---|---|
| Sex | Male | 41,075 (43.66) | 35,307 (44.14) | 5507 (40.70) | 261 (47.60) | 1 | 1 |
| Female | 52,832 (56.16) | 44,531 (55.67) | 8014 (59.22) | 287 (52.40) | 0.88 (0.84–0.91) | 1.20 (1.01–1.42) | |
| Missing | 166 (0.18) | 155 (0.19) | 11 (0.08) | - | |||
| Age, years | 0–1 | 2174 (2.31) | 1816 (2.27) | 358 (2.70) | - | 1.19 (1.06–1.34) | - |
| 2–11 | 2954 (3.14) | 2003 (2.50) | 948 (7.00) | 3 (0.55) | 2.97 (2.74–3.22) | 0.21 (0.07–0.66) | |
| 12–17 | 1616 (1.72) | 1222 (1.53) | 386 (2.90) | 8 (1.46) | 1.88 (1.68–2.12) | 0.97 (0.48–1.95) | |
| 18–65 | 42,303 (44.97) | 33,289 (41.61) | 8657 (64.00) | 357 (65.14) | 2.48 (2.39–2.58) | 2.63 (2.21–3.14) | |
| >65 | 44,866 (47.69) | 41,518 (51.90) | 3170 (23.40) | 178 (32.48) | 0.28 (0.27–0.29) | 0.44 (0.37–0.53) | |
| Missing | 160 (0.17) | 145 (0.19) | 13 (0.09) | 2 (0.37) | |||
| Mean (±SD) | 58.50 ± 23.90 | 60.59 ± 23.46 | 46.28 ± 22.98 | 55.70 ± 17.67 | |||
| Ethnicity | Caucasian | 75,668 (80.44) | 64,158 (80.20) | 11,059 (81.72) | 451 (82.30) | 1.12 (1.07–1.78) | 1.16 (0.93–1.45) |
| Other | 2953 (3.14) | 2330 (2.92) | 603 (4.46) | 20 (3.65) | - | - | |
| Missing | 15,452 (16.42) | 13,505 (16.88) | 1870 (13.82) | 77 (14.05) | |||
| Triage codes | Red | 2672 (2.84) | 2251 (2.81) | 292 (2.16) | 129 (23.54) | 0.86 (0.76–0.97) | 10.68 (8.69–13.13) |
| Yellow | 18,596 (19.77) | 16,037 (20.05) | 2376 (17.56) | 183 (33.39) | 0.92 (0.88–0.97) | 2.00 (1.68–2.39) | |
| Green | 36,045 (38.32) | 29,748 (37.19) | 6235 (46.07) | 62 (11.31) | 1.29 (1.24–1.34) | 0.22 (0.17–0.28) | |
| White | 3436 (3.65) | 2719 (3.40) | 717 (5.30) | - | 1.25 (1.15–1.37) | - | |
| Missing | 33,324 (35.42) | 29,238 (36.55) | 3912 (28.91) | 174 (31.76) | |||
| Hospitalization | Yes | 26,644 (28.32) | 24,168 (30.20) | 2105 (15.60) | 371 (67.70) | 0.53 (0.50–0.55) | 5.62 (4.66–6.79) |
| No | 67,429 (71.68) | 55,825 (69.80) | 11,427 (84.40) | 177 (32.30) | - | - |
CI: confidence interval; IQR: interquartile range; ROR: reporting odds ratio; SD: standard deviation. Logistic regression analyses were used to estimate the reporting odds ratios (RORs) with 95% confidence intervals (CIs) of drug-related allergies and anaphylaxis adjusting for sex, age classes, and ethnicity.