Table 3.
List of drugs and the relevant metabolic enzymes and targets investigated.
| Drug | Type | CYP Enzymes | Targets |
|---|---|---|---|
| Amitriptiline | TCA | CYP2C19, CYP2D6 | 5HTT, 5-HT2A |
| Aripiprazole | SGA | CYP2D6 | |
| Atomoxetine | NRI | CYP2D6 | |
| Citalopram | SSRI | CYP2C19 | 5-HTT |
| Clomipramine | TCA | CYP2C19, CYP2D6 | 5-HTT, 5-HT2A |
| Clozapine | SGA | CYP1A2, CYP2C19 | |
| Desvenlafaxine | SNRI | 5-HTT | |
| Duloxetine | SNRI | CYP2D6 & CYP1A2 | 5-HTT |
| Escitalopram | SSRI | CYP2C19, | 5-HTT |
| Fluoxetine | SSRI | CYP2D6 | 5-HTT |
| Fluvoxamine | SSRI | CYP2D6 | 5-HTT |
| Haloperidol | FGA | CYP2D6 | |
| Imipramine | TCA | CYP2C19, CYP2D6 | 5-HTT |
| Maprotiline | TCA | CYP2D6 | |
| Mirtazapine | TCA | CYP2D6, CYP1A2 | 5-HT2A |
| Nortriptyline | TCA | CYP2D6 | 5-HTT, 5-HT2A |
| Olanzapine | SGA | CYP1A2 | |
| Paroxetine | SSRI | CYP2D6 | 5-HTT |
| Risperidone | SGA | CYP2D6 | |
| Sertraline | SSRI | CYP2C19 | 5-HTT |
| Venlafaxine | SNRI | CYP2D6 | 5-HTT |
| Vortioxetine | SMS | CYP2D6 | 5-HTT |
Abbreviations: FGA: first-generation antipsychotics, SGA: second-generation antipsychotic, SNRI: serotonin-norepinephrine reuptake inhibitor, SSRI: selective serotonin reuptake inhibitor, SMS: serotonin modulator and stimulator, TCA: tricyclic antidepressant.