Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
CRS Protease mechanisms. SARS-CoV-2 S protein can be cleaved by furin at positions 685–686 and 3CLpro at glutamine positions through CRS mechanisms. The catalytic center of furin is the triad Asp—His—Ser, and for 3CL protease is the dyad Cys145—His41. Two of the four main mechanistic classes of proteases are (a) serine proteases as in the furin cleavage, and (b) cysteine proteases as in the 3CLpro hydrolysis [53].
