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. 2022 May 10;15(5):587. doi: 10.3390/ph15050587

Figure 1.

Figure 1

Automated radiosynthesis of [18F]DTG on a TRACERlab® FX N Pro module. Radiofluorination (red square) takes place in reactor 1, whereas the nitrile reduction and peptide coupling reactions (blue square) take place in reactor 2. Ready-to-inject [18F]DTG (orange square) is obtained after semi-preparative HPLC purification and SPE formulation. Reagents and conditions: (i) K [18F]F, K222, K2CO3, DMSO, 95 °C, 5 min; (ii) NaBH4 2M (20 µL), NiCl2·6H2O (25 mg), MeOH, H2O (100 µL), r.t., 5 min; (iii) 3, TBTU, DIPEA, DMF, r.t., 10 min.