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. 2022 May 17;14(5):1068. doi: 10.3390/pharmaceutics14051068

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Influence of HA and CV on in vivo antimetastatic properties of M1-derived EVs loaded with DOX in orthotopic 4T1 breast cancer-bearing mice. (A) H&E staining of liver sections from treated animals showing the formation of metastatic niches. (B) Percentage of liver metastatic niches for the four experimental groups. (C) H&E staining of lung sections from treated animals showing the formation of metastatic niches. (D) Percentage of lung metastatic niches for the four experimental groups. (E) Immunohistochemical (IHC) detection of CXL12 in liver sections from treated animals. (F) IHC score for CXL12 from the four experimental groups. (G) IHC detection of CXL12 in lung sections from treated animals. (H) IHC score for CXL12 from the four experimental groups. Scale bars are 20 µM. Data are means ± SEM. Non-significant (ns); **** p < 0.0001; *** p < 0.001; ** p < 0.01; * p < 0.05.