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. 2022 May 17;14(5):1068. doi: 10.3390/pharmaceutics14051068

Figure 6.

Figure 6

In vivo antimetastatic properties of MM1-derived EVs loaded with DOX in orthotopic 4T1 breast cancer-bearing mice in vivo. (A) Immunohistochemical (IHC) detection of MMP-2 in tumor sections from treated animals. (B) IHC score for MMP-2 from the four experimental groups. (C) Immunofluorescence detection of tumor growth factor beta (TGF-β) in tumor sections of treated animals. (D) Mean fluorescence intensity of TGF-β in the four experimental groups. (E) IHC detection CD163 in tumor sections from treated animals. (F) IHC score for CD163 from the four experimental groups. Scale bars are 20 µM. Data are means ± SEM (n = 5 mice per condition). Non-significant (ns); **** p < 0.0001; *** p < 0.001; ** p < 0.01; * p < 0.05.