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. 2022 May 20;14(5):1097. doi: 10.3390/pharmaceutics14051097

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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MNs for delivery of insulin (a) Formation and mechanism of GRVs composed of HS-HA. (b) Schematic of the GRV-containing MN-array patch (smart insulin patch) for in vivo insulin delivery triggered by a hyperglycemic state to release more insulin [238]. (Adapted from Ref. [238]).