Histopathological changes in the placenta. (A–C) Control placenta (uninfected) with regular aspects: (A) decidua and chorionic villi, (B) chorionic villi, and (C) decidua. (D–K) CHIKV-infected placenta: (D–E) deciduitis (Dec); (F) fibrin deposition (Fi) and fibrosis (Fs); (G) edema (E) in intervillous space (Is), edema inside fetal capillaries (Fc), and fibrin deposition (Fi); (H) fetal vessel thickening (Vs); (I) edema (E) in chorionic villi, extramedullary hematopoiesis (H); (J,K) chorioamnionitis (C) in lower and higher magnification, respectively. Scale bar—(A,D,G,H,J): 100 µm; (B,I): 20 µm; (C,F,K): 50 µm.