Table 3.
A comparative illustration of thymoquinone (TQ) effects on mRNA gene expression in MDA-MB-231 and MDA-MB-468 TNBC cells following a 24 h exposure period.
| A. MDA-MB-231 | B. MDA-MB-468 | ||||
|---|---|---|---|---|---|
| Gene | Fold Change | p-Value | Gene | Fold Change | p-Value |
| TRAF2 | +2.3 | 0.0011 | FADD | +14.86 | 0.0005 |
| CASP3 | +1.8 | 0.0028 | TNFRSF10A | +27.67 | 0.0006 |
| BAG1 | +2.7 | 0.0045 | TNF | +26.07 | 0.0032 |
| TRAF3 | +1.9 | 0.0063 | ACTB | +6.39 | 0.0089 |
| ACTB | +2.1 | 0.0088 | BAD | +5.03 | 0.0110 |
| BCL10 | +2.1 | 0.0088 | TNFRSF10B | +11.39 | 0.0154 |
| BNIP3 | +3.2 | 0.0103 | BAG1 | +11.38 | 0.0178 |
| CASP9 | +3.7 | 0.0175 | TRAF2 | +11.42 | 0.0193 |
| TP53 | +2.5 | 0.0233 | BAX | +6.71 | 0.0178 |
| TNFRSF10A | +2.3 | 0.0248 | DAPK1 | +2.98 | 0.0285 |
| DIABLO | +2.0 | 0.0259 | APAF1 | +3.69 | 0.0208 |
| MCL1 | +1.8 | 0.0332 | AKT1 | +5.39 | 0.0220 |
| CASP4 | +2.4 | 0.0233 | TNFRSF21 | +4.75 | 0.0308 |
| DFFA | +2.8 | 0.0248 | TNFRSF11B | +15.93 | 0.0422 |
| GADD45A | +4.5 | 0.0398 | BIK | +9.36 | 0.0432 |
| BIRC5 | −3.58 | 0.04398 | CASP2 | +3.58 | 0.0457 |