Table 2.
Detailed group characteristics.
| Characteristic | Experimental Group | Control Group 1 | Control Group 2 | p1 | p2 |
|---|---|---|---|---|---|
| n = 89 | 61 | 20 | 8 | ||
| Age, M ± SD | 34.03 ± 7.32 | 36.40 ± 7.59 | 32.88± 7.77 | 0.217 1 | 0.667 1 |
| Number of term pregnancies, n (%) | |||||
| 0 | 26 (42.6) | 7 (35.0) | 5 (62.5) | 0.873 | 0.249 |
| 1 | 18 (29.5) | 8 (40.0) | 0 (0.0) | ||
| 2 | 14 (23.0) | 4 (20.0) | 3 (37.5) | ||
| 3 | 3 (4.9) | 1 (5.0) | 0 (0.0) | ||
| Number of pre-term pregnancies, n (%) | |||||
| 0 | 60 (98.4) | 20 (100.0) | 8 (100.0) | >0.999 | >0.999 |
| 1 | 1 (1.6) | 0 (0.0) | 0 (0.0) | ||
| Number of miscarriages, n (%) | |||||
| 0 | 55 (91.2) | 18 (90.0) | 8 (100.0) | 0.797 | >0.999 |
| 1 | 4 (6.6) | 2 (10.0) | 0 (0.0) | ||
| 2 | 2 (3.2) | 0 (0.0) | 0 (0.0) | ||
| Number of pregnancies, Me (Q1; Q3) | 1.00 (0.00; 2.00) | 1.00 (0.00; 2.00) | 0.00 (0.00; 2.00) | 0.991 2 | 0.421 2 |
| Comorbidities, n (%) | 22 (37.7) | 6 (30.0) | 1 (12.5) | 0.600 | 0.246 |
| Cytology, n (%) | 61 | 20 | 8 | ||
| NILM | 7 (11.5) | 12 (60.0) | 0 (0.0) | 0.001 | 0.903 |
| ASCUS | 12 (19.7) | 5 (25.0) | 2 (25.0) | ||
| ASC-H | 10 (16.4) | 1 (5.0) | 1 (12.5) | ||
| LSIL | 20 (32.8) | 1 (5.0) | 3 (37.5) | ||
| HSIL | 6 (9.8) | 1 (5.0) | 2 (25.0) | ||
| AGC | 2 (3.3) | 0 (0.0) | 0 (0.0) | ||
| Virgin | 3 (4.9) | 0 (0.0) | 0 (0.0) | ||
| Cervical cancer | 1 (1.6) | 0 (0.0) | 0 (0.0) | ||
| HPV, n (%) | 61 | 20 | 8 | ||
| Positive | 52 (85.2) | 2 (10.0) | 8 (100.0) | <0.001 | >0.999 |
| Negative | 6 (9.9) | 18 (90.0) | 0 (0.0) | ||
| Virgin | 3 (4.9) | 0 (0.0) | 0 (0.0) | ||
| Biopsy, n (%) | n = 57 | n = 8 | n = 8 | ||
| NILM | 11 (19.3) | 8 (100.0) | 0 (0.0) | <0.001 | 0.285 |
| LSIL (CIN 1) | 17 (29.8) | 0 (0.0) | 1 (12.5) | ||
| HSIL (CIN2, CIN 3) | 28 (49.1) | 0 (0.0) | 7 (87.5) | ||
| Adenocarcinoma | 1 (1.8) | 0 (0.0) | 0 (0.0) | ||
| Antibody level, Me (Q1; Q3) | 1.77 (1.22; 2.35) | 0.09 (0.07; 0.19) | 0.13 (0.07; 0.44) | <0.001 2 | <0.001 2 |
| Antibody level/cut-off, Me (Q1; Q3) | 5.83 (4.01; 7.77) | 0.29 (0.22; 0.62) | 0.41 (0.23; 1.45) | <0.001 2 | <0.001 2 |
| Reactive, n (%) | 61 (100.0) | 3 (15.5) | 2 (25.0) | <0.001 | <0.001 |
NILM—negative for intraepithelial lesion or malignancy; ASCUS—atypical squamous cells of undetermined significance; ASC-H—atypical squamous cells cannot exclude HSIL; LSIL—low-grade squamous intraepithelial lesion; HSIL—high-grade squamous intraepithelial lesion; AGC—atypical glandular cells; Q1—first quartile; Q3—third quartile; n—number, p1—p-value for comparison between experimental group and control group 1; p2—p-value for comparison between the experimental group and control group 2. Comparisons were made with Student’s t test 1 or Mann–Whitney U test 2 for quantitative variables and Fisher’s exact test for qualitative variables.