Table 2.

Pharmacokinetic and drug excretion properties of naphthoquinone derivatives 9 and 16 and their comparison to standard chemotherapy agent doxorubicin.

Compound	GI Absorption	BBB Permeant	P-gp Substrate	CYP1A2 Inhibitor	CYP2C19 Inhibitor	CYP2C9 Inhibitor	CYP2D6 Inhibitor	CYP3A4 Inhibitor
9	High	Yes	No	Yes	Yes	Yes	Yes	Yes
16	High	No	No	Yes	No	Yes	No	Yes
DOX	Low	No	Yes	No	No	No	No	No

Abbreviations: P-gp—P glycoprotein 1; BBB—blood–brain barrier; GI—gastrointestinal; CYP1A2—Cytochrome P450 1A2; CYP2C19—Cytochrome P450 2C19; CYP2C9—Cytochrome P450 2C9; CYP2D6—Cytochrome P450 2D6; CYP3A4—Cytochrome P450 3A4; DOX—doxorubicin.