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. 2022 May 17;23(10):5624. doi: 10.3390/ijms23105624

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Our proposed model of the mechanism underlying the antitumor effects of crassolide on NSCLC cells. Crassolide induces autophagy-mediated cell death and G2/M arrest in human H460 NSCLC cells via ROS-mediated ER stress pathway activation.