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. 2022 Apr 22;14(5):917. doi: 10.3390/pharmaceutics14050917

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Construction of the low-pH-targeted MSN NP for photoacoustic imaging of pancreatic ductal adenocarcinoma. (A) Schematic Illustration of the Components and Formation of V7-TROS NPs, including V7-TMOS, V7-TEOS and V7-TPOS. (B) Conjugation Chemistry of SMCC to the Cysteine Residue on the V7 Peptide, and (C) the Activation Mechanism of the V7 Peptide in Acidic Environments. (D) Biodistribution of V7-TMOS in axial slices showing accumulation within the tumor, kidney, liver, and spleen Figures were adapted based Refs. [77,154] with permissions. Copyright 2021 American Chemical Society.