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. 2022 Apr 29;10(5):707. doi: 10.3390/vaccines10050707

Figure 3.

Figure 3

Primary and continuous cell lines tested for ASFV susceptibility. The main targets of ASFV are porcine monocytes and macrophages. Established cell lines were tested to support virus growth for the production of antiviral drugs, virus–host interaction studies, the construction of mutants, specific diagnostic systems, and the large-scale production of a safe and efficient vaccine. The established cell line has to have susceptibility to several ASFV strains, be not expensive to produce or time-consuming, be ethical, and able to maintain the genome stability of the virus. Considering all the cells tested thus far, the most promising continuous cell lines for LAV production are WSL, PIPEC, and ZMAC-4; however, future studies are still needed. Created with BioRender.com (accessed on 7 March 2022). PAMs: porcine alveolar macrophages; IPAM: immortalized porcine alveolar macrophages; IPKM: immortalized porcine kidney macrophages; PIPEC: Plum Island porcine epithelial cells; ZMAC-4: Zuckerman macrophage-4; and LAV: live attenuated vaccine.