Table 6.
COOH-Cannabidiol Pharmacokinetic Parameters.
| Parameter | 088 | 126 | 213 | 625 | 725 | |
|---|---|---|---|---|---|---|
| Tmax (min) |
Mean SD Median Range n |
175.7 c,d,e,f 49.7 180.0 120–240 14 |
93.2 *,d 40.0 90.0 45–180 14 |
111.4 b,f 32.1 120.0 60–180 14 |
210.0 *,a,b,c 45.6 240.0 120–240 14 |
111.4 a,e 32.1 120.0 60–180 14 |
| Cmax (ng/mL) |
Mean SD Median Range n |
15.6 a,f 9.1 14.4 3.6–33.4 14 |
86.7 *,a,b,c 58.2 72.3 21.1–249.7 14 |
59.3 c,d 29.8 51.4 11.7–118.7 14 |
12.2 *,d,e 11.8 7.4 1.2–42.9 14 |
53.8 b,e,f 22.9 51.6 13.4–108.4 14 |
| AUC0–4 (min × ng/mL) |
Mean SD Median Range n |
2284.9 a,e,g 1361.2 2276.1 547–5275 14 |
14907.4 *,a,b,c 10354.6 12327.3 3778–43275 14 |
10233.4 c,d,e 5421.8 8900.2 2127–23257 14 |
1743.7 *,d,f 1907.4 974.0 183–7126 14 |
9457.3 b,f,g 4263.4 7923.3 2432–20208 14 |
| AUC0–inf (min × ng/mL) |
Mean SD Median Range n |
- - - - - |
- - - - - |
- - - - - |
- - - - - |
- - - - - |
| t½ (min) |
Mean SD Median Range n |
- - - - - |
408.6 292.0 296.4 154.9–981.1 7 |
385.8 150.1 431.4 218.2–507.9 3 |
- - - - - |
282.5 26.6 267.8 266.4–313.2 3 |
| Ke (1/h) |
Mean SD Median n |
- - - - |
0.002 0.001 0.000 7 |
0.002 0.001 0.000 3 |
- - - - |
0.002 0.000 0.000 3 |
| Vd (mL) |
Mean SD Median n |
- - - - |
- - - - |
- - - - |
- - - - |
- - - - |
See Table 3 and manuscript text for abbreviation definitions. Values sharing the same superscript letter or symbol are different (p < 0.05).