Table 3.
Pharmacokinetic parameters of MXD obtained from male and female Qinghai Tibetan sheep.
| Parameters | Male | Female |
|---|---|---|
| T1/2β (day) | 13.08 ± 8.10 | 19.35 ± 3.97 |
| Tmax (day) | 0.24 ± 0.14 | 0.53 ± 0.46 |
| Cmax (ng/mL) | 415.19 ± 58.93 | 231.80 ± 112.39 |
| AUC0–t (day·ng/mL) | 4690.86 ± 472.67 ** | 1880.26 ± 334.62 |
| AUC0–∞ (day·ng/mL) | 5008.83 ± 525.14 ** | 2095.99 ± 478.20 |
| Vd (mL/kg) | 3729.00 ± 2077.32 * | 13736.91 ± 4110.70 |
| CL (mL/day/kg) | 201.18 ± 21.90 ** | 492.22 ± 99.44 |
| MRT0-t (day) | 25.22 ± 0.79 | 21.22 ± 5.14 |
| MRT0-∞ (day) | 29.6 ± 3.56 | 28.66 ± 4.52 |
Note: T1/2β = Terminal elimination half-life; Tmax = Time to peak plasma concentration; Cmax = Peak plasma concentration; AUC = Area under the concentration–time curve; Vd = Apparent volume of distribution; CL = Total body clearance; MRT = Mean residence time. * p < 0.05, ** p < 0.01.