Table 3.
PA01 and MDR 7067 P. aeruginosa planktonic strains are susceptible after 24 h exposure (i.e., MIC) and 48 h exposure after biofilm-grown isolates (i.e., BIC) to free tobramycin, tobramycin-loaded liposomal formulations, empty liposomes, and peptide-loaded liposomes.
| Formulations | MIC (μg/mL) | |||
|---|---|---|---|---|
| PA01 | MDR 7067 | |||
| 24 h | 48 h | 24 h | 48 h | |
| Tobramycin | ≤0.5 | 32 | 256 | >1024 |
| Liposomes + Tobramycin | ≤0.5 | 32 | 256 | >1024 |
| Liposomes + Tobramycin + IDR-1018 | ≤0.5 | 32 | 256 | >1024 |
| Empty Liposomes | >1024 | >1024 | >1024 | >1024 |
| Liposomes + IDR-1018 | >1024 | >1024 | >1024 | >1024 |