Table 2.
Biochemistry parameters of the treatment group (Bio) during the study (d0—before the treatment, d100—at day 100 of treatment, d200- at day 200 of treatment), and the evaluation of the overall absolute and relative changes (d200 vs. d0 values) explained by Cohen delta.
| Parameter | Bio(d0) (±sR) |
Bio(d100) (±sR) |
Bio(d200) (±sR) |
Bio(d200-d0) (±sR) |
Absolute Treatment Effect Cohen delta |
Bio(d200-d0)/Bio(d0) (±s Bio) |
Relative Treatment Effect Cohen Delta |
|---|---|---|---|---|---|---|---|
| GSH | 0.36 (±0.40) |
0.48 (±0.44) |
0.78 (±0.65) |
0.42 (±0.66) |
0.58 ++ | 2.74 (±3.48) |
0.73 ++ |
| GSSG | 1.48 (±0.54) |
1.57 (±1.34) |
1.36 (±0.66) |
−0.11 (±0.73) | −0.14 | 0.05 (±0.69) |
0.06 |
| GSH/GSSG | 0.26 (±0.26) |
0.39 (±0.33) |
0.66 (±0.59) |
0.40 (±0.51) |
0.73 ++ | 3.15 (±4.26) |
0.69 ++ |
| Vit. B12 | 408.48 (±474.9) |
601.33 (±404.92) |
628.64 (±209.95) |
211.33 (±423.46) | 0.46 ++ | 1.03 (±0.93) |
1.02 +++ |
| Homocysteine | 3.69 (±1.21) |
3.47 (±0.87) |
4.02 (±1.17) |
0.29 (±1.14) |
0.23 + | 0.14 (±0.38) |
0.34 + |
| Cysteine | 95.29 (±39.79) |
85.35 (±32.01) |
115.68 (±30.58) |
19.69 (±44.40) |
0.42 ++ | 0.43 (±0.91) |
0.44 ++ |
Note: Rv(d200-d0) and Rv(d200-d0)/d0 are means of differences obtained for individual patients. Patients missing either d0 or d200 values were not included in the calculation. + Small treatment effect. ++ Medium treatment effect. +++ Large treatment effect.