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. 2022 Apr 29;15(5):554. doi: 10.3390/ph15050554

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Evaluation of the second-generation inhibitors. (A) Structures of the potential second- generation inhibitors of cN-IIIB enzyme. (B) Inhibitory potency and hydrolysis of 14 compounds of the second library, which includes 6 leading compounds from the first library. Inhibitory potency was introduced as the % of m⁷GMP—substrate dephosphorylation by cN-IIIB enzyme in the presence of inhibitor. Depending on the solubility of compounds, their stock solution was dissolved in water or DMSO, and the graph presents the control reaction for both solvents. The data represent mean values ± SD from triplicate.