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. 2022 May 18;23(10):5652. doi: 10.3390/ijms23105652

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effects of curcumin or curcuminoid treatment on relaxation response of the isolated aorta to acetylcholine (ACh) before (A–D) and after preincubation with ascorbic acid (E–I) from Wistar rats (A,E), GK control rats (F), GK Vehicle rats (B,G) and GK rats administered with curcumin (C,H) or curcuminoid (D,I). W: Wistar control; GK: Goto-Kakizaki control; Vh: Goto-Kakizaki submitted to vehicle (DMSO) administration; Curcumin: Goto-Kakizaki submitted to curcumin administration (40 mg/Kg/day, s.c.) and Curcuminoid: Goto-Kakizaki submitted to curcuminoid (52.4 mg/Kg/day, s.c.) administration. Relaxation is presented as percentage of NA induced contraction; results are expressed as mean ± S.E.M.; n = 5–6/group; statistical differences were evaluated by Student t-test. # vs. GK; * vs. Control. 1 symbol p < 0.05; 2 symbol p < 0.01; 3 symbol p < 0.001.