Figure 1.

The cytopathic effect-based high-throughput screening identifies new antiviral agents against AdV replication. Vero cells were incubated with five μM of each library compound for 10 min and followed by the infection with the AdV3 at MOI 0.56 or AdV5 at MOI 1.1. After incubation at 37 °C for 48 hrs, cell viability and inhibition rates were determined. Graphs show the percentage of inhibition rates against AdV3 (A) or AdV5 (B) of all drugs in each category of drug target. The inhibition rate for each category is presented as mean ± SEM. The total compound number in each category is indicated in parentheses.