Table 2.
Anti-ADV activities of hit compounds targeting PI3K/Akt/mTOR.
| Target | Name | CC50 (µM) | EC50 (µM) | Selective Index | ||
|---|---|---|---|---|---|---|
| AdV3 | AdV5 | AdV3 | AdV5 | |||
| PKA 1 | H 89 2HCl | >5.00 | 0.31 | >5.00 | >15.97 | ND 5 |
| PI3K 2 | VS-5584 | 0.40 | 0.10 | 0.10 | 3.94 | 4.18 |
| GNE-317 | >5.00 | 0.26 | 0.59 | 19.28 | 8.50 | |
| Akt 3 | LY3023414 | >5.00 | 0.90 | 1.31 | >5.58 | >3.83 |
| mTOR 4 | AZD8055 | >5.00 | 0.11 | 0.16 | >44.72 | >31.87 |
| PP242 | >5.00 | 1.03 | 1.97 | >4.85 | >2.54 | |
| OSI-027 | >5.00 | 1.38 | 2.40 | >3.62 | >2.08 | |
| WYE-125132 | >5.00 | 0.06 | 0.15 | >89.17 | >32.47 | |
| WAY-600 | 3.11 | 0.56 | 1.09 | 5.51 | 2.86 | |
| GDC-0980 | 3.00 | 0.08 | 0.27 | 36.44 | 10.96 | |
| PF-04691502 | >5.00 | 0.06 | 0.12 | >86.01 | >41.46 | |
| AZD2014 | 4.05 | 0.02 | 0.07 | 171.31 | 56.82 | |
| INK 128 | 0.85 | 0.01 | 0.01 | 161.78 | 61.27 | |
| Torin 2 | 0.78 | 0.31 | 0.09 | 2.48 | 8.30 | |
| Voxtalisib | 2.26 | 0.47 | 2.72 | 4.83 | 0.83 | |
| CC-223 | >5.00 | 1.11 | 1.38 | >4.50 | >3.62 | |
| GDC-0349 | >5.00 | 1.38 | 2.62 | >3.63 | >1.91 | |
1 PKA: (cAMP-dependent) protein kinase A; 2 PI3K: Phosphoinositide 3-kinase. 3 Akt: Protein kinase B; 4 mTOR: Mammalian target of rapamycin. 5 ND: Not determined.