Table 4.
Anti-ADV activities of hit compounds targeting other host pathways.
| Pathway | Target | Name | CC50 (µM) | EC50 (µM) | Selective Index | ||
|---|---|---|---|---|---|---|---|
| AdV3 | AdV5 | AdV3 | AdV5 | ||||
| Cell Cycle | Aurora Kinase 1 | ENMD-2076 L-(+)-Tartaric acid | 4.34 | 1.35 | 1.39 | 3.22 | 3.14 |
| AMG-900 | 3.69 | 0.02 | >5.00 | 226.12 | ND 9 | ||
| CDK 2 | BMS-265246 | >5.00 | 0.64 | 0.6 | >7.84 | >8.35 | |
| ON123300 | >5.00 | 2.91 | 1.62 | >1.72 | >3.08 | ||
| Transmembrane Transporters |
CRM1 3 | KPT-276 | >5.00 | 0.1 | 0.97 | >50.46 | >5.13 |
| KPT-330 | 1.58 | 0.1 | 0.52 | 15.45 | 3.04 | ||
| KPT-335 | 1.9 | 0.15 | 0.61 | 12.65 | 3.14 | ||
| MAPK | p38 MAPK 4 | Doramapimod | >5.00 | 0.35 | >5 | >14.24 | ND |
| PH-797804 | >5.00 | 0.02 | 1.58 | >250.00 | >3.16 | ||
| Skepinone-L | 2.14 | 0.18 | 2.56 | 11.84 | 0.83 | ||
| Raf 5 | RAF265 | >5.00 | 1.28 | >5.00 | >3.91 | ND | |
| TAK-632 | 1.99 | 0.18 | 0.16 | 11.15 | 12.3 | ||
| TGF-beta/Smad | PKC 6 | Go6976 | 3.95 | 0.62 | 1.23 | 6.39 | 3.22 |
| Metabolism | IMPDH 7 | Mycophenolate Mofetil | >5.00 | 1.84 | 0.19 | >2.72 | >25.83 |
| DHODH 8 | Vidofludimus | >5.00 | 1.63 | 0.94 | >3.07 | >5.35 | |
1 Aurora Kinase: A serine/threonine kinase; 2 CDK: Cyclin-dependent kinase. 3 CRM1: Chromosomal Maintenance 1, also known as Exportin 1. 4 p38 MAPK: p38 mitogen-activated protein kinase; 5 Raf: rapid accelerated fibrosarcoma, a family of three serine/threonine-specific kinases (A-Raf, B-Raf, and Raf-1). 6 PKC: Potent protein kinase C. 7 IMPDH: Inosine monophosphate dehydrogenase. 8 DHODH: Dihydroorotate dehydrogenase; 9 ND: Not determined.