Table 2.
Subgroup analysis according to key categorical variables.
| Variable | Cohorts | N in Subgroup | Pooled Risk with Random Effects (95% CI) | I2 (%) | Test for Subgroup Effect (p-Value) |
|---|---|---|---|---|---|
| Treatment | |||||
| Anti-CD20 | 9 | 226 | 0.25 (0.17–0.36) | 50.7 | < 0.0001 |
| Non-anti-CD20 | 6 | 114 | 0.81 (0.72–0.87) | 0.0 | |
| Disease | |||||
| Only RA | 3 | 76 | 0.51 (0.12–0.89) | 90.0 | 0.0286 |
| Only SLE | 1 | 8 | 0.94 (0.50–1.00) | NIL | |
| Only ANCA vasculitis | 2 | 36 | 0.53 (0.37–0.68) | 0.0 | |
| Only MS | 1 | 16 | 0.06 (0.01–0.34) | NIL | |
| Age | |||||
| <50 | 1 | 8 | 0.94 (0.50–1.00) | NIL | 0.0571 |
| 50–65 | 7 | 269 | 0.36 (0.20–0.56) | 86.8 | |
| >65 | 3 | 46 | 0.52 (0.38–0.66) | 0.0 | |
| Vaccine type | |||||
| Only mRNA | 6 | 163 | 0.34 (0.16–0.58) | 83.5 | 0.0049 |
| Only viral vector | 1 | 27 | 0.22 (0.10–0.41) | NIL |
Abbreviations: RR, risk ratio; CI, confidence interval.