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. 2022 May 12;11(10):1295. doi: 10.3390/plants11101295

Table 2.

Cytotoxic activity of the isolated compounds from Tylophora indica using MTT assays.

No. Compounds IC50 ± SD (μM) a
MCF-7 HepG2 HCT-116
1. Tylophorine 126.5 40.10 ± 2.94 142.20 ± 3.06
2. Tylophorinicine 50.71 ± 2.86 35.33 ± 2.97 75.55
3. Tylophorinine 31.96 ± 2.64 23.8 ± 3.02 86.95 ± 3.08
4. Tylophorinine N-Oxide ˃200 196.60 ˃200
5. Tylophorinidine 6.45 ± 2.06 4.77 ± 2.11 20.08 ± 1.94
6. Tylophorinidine-N-Oxide 12.15 ± 1.81 15.31 ± 2.04 65.62 ± 2.24
7. Septicine ˃200 ˃200 ˃200
8. Chlorogenic acid 134.00 169.90 ˃200
9. Chlorogenic acid methyl ester ˃200 ˃200 ˃200
10. Cisplatin (Reference) 5.70 ± 0.76 12.93 ± 0.91 14.42 ± 1.69

a IC50: Inhibitory concentration for 50%.