. 2022 May 10;14(5):334. doi: 10.3390/toxins14050334

Table 2.

Cytotoxicity of N. kaouthia, N. sumatrana, and N. atra venoms and NK-CTX, NS-CTX, and NA-CTX in CRL-2648 cells and neutralization by NBAV, NkMAV, and SAV.

Venom/Toxin	IC₅₀ (Untreated) ^a (μg/mL)	NkMAV			SAV			NBAV
Venom/Toxin	IC₅₀ (Untreated) ^a (μg/mL)	IC₅₀ (Treated) ^b (μg/mL)	Antivenom Concentration (μg/mL)	Pc ^c (mg/g)	IC₅₀ (Treated) ^b (μg/mL)	Antivenom Concentration (μg/mL)	Pc ^c (mg/g)	IC₅₀ (Treated) ^b (μg/mL)	Antivenom Concentration (μg/mL)	Pc ^c (mg/g)
N. kaouthia (Thailand)	47.40 ± 6.50	69.17 ± 8.39	125	174.16	82.17 ± 0.85	125	278.16	64.20 ± 7.00	125	134.40
N. sumatrana (Malaysia)	28.83 ± 2.86	37.47 ± 2.77	500	17.28	41.50 ± 1.25	500	25.34	36.50 ± 2.95	500	15.34
N. atra (Taiwan)	26.87 ± 8.86	49.60 ± 8.47	500	45.46	61.80 ± 6.73	500	69.86	43.53 ± 6.48	500	33.32
NK-CTX	32.90 ± 3.11	39.50 ± 2.40	500	13.20	38.23 ± 1.48	125	42.64	35.17 ± 7.10	500	4.54
NS-CTX	20.90 ± 3.73	39.33 ± 2.82	500	36.86	45.77 ± 9.40	500	49.74	36.10 ± 4.08	500	30.40
NA-CTX	13.17 ± 2.72	24.87 ± 1.36	500	23.40	31.50 ± 2.71	500	36.66	24.97 ± 1.95	500	23.60

NkMAV: Thai Naja kaouthia monovalent antivenom; SAV: Vietnamese Naja kaouthia monovalent antivenom; NBAV: Taiwanese neurobivalent antivenom; IC₅₀: Half maximal inhibitory concentration; Pc: Potency. ^a IC₅₀(Untreated), defined as half maximal inhibitory concentration of venom/cytotoxin without antivenom. ^b IC₅₀(Treated), defined as half maximal inhibitory concentration of venom/cytotoxin with antivenom treatment. ^c Pc, Potency, defined as amount of venom/cytotoxin, in mg, neutralized by 1 g of antivenom.