Figure 3.

Mismatch Repair (MMR) Pathway. MutS and MutL start DNA repair by recognizing and binding to mismatches. PCNA and RFC will be recruited to the site of damage to initiate repair. These interactions will lead to the recruitment of Exo1 to a strand break where it will excise the damaged DNA from the nick up to and beyond the mismatch depending on the MutS, MutL, and RPA. During DNA resynthesis, DNA Pol δ will use the parental strand as a template to repair the mismatch, followed by DNA Lig I ligation. The orange star denotes DNA mismatch.