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Canonical Non-Homologous End Joining (c-NHEJ) Pathway to Repair DSBs. (A) 53BP1 directs the repair pathway to NHEJ by inhibiting BRCA1 and end resection. The Ku80/Ku70 heterodimer binds to the DNA ends, aligns them, and recruits DNA PKcs to the DSB to activate its kinase domain. (B) DNA PKcs is autophosphorylated and will activate ARTEMIS resulting in limited resection. (C) The Ligase Complex, DNA Lig IV, and XRCC4 will stabilize the positioning of the ends before restoring the break.
