Table 3.

Effects of cannabidiol (CBD) on locomotor alterations induced by other substances.

Species	Substance	CBD	Locomotor Activity	Reference
Rat	Single i.p. rimonabant (0.1 mg/kg; i.p.)	Single i.p. CBD (20 mg/kg)	No effect of rimonabant on CBD-induced reduction of vertical activity.	[69]
	Single i.p. WAY-100,635 (0.5 mg/kg)	Single i.p. CBD (20 mg/kg)	WAY-100,635 restored CBD-induced reduction of vertical activity.
	Single i.p. 8-OH-DPAT (1 mg/kg)	Single i.p. CBD (20 mg/kg)	CBD potentiated 8-OH-DPAT reduction of vertical activity.
Rat	Single oral haloperidol (5 mg/kg)	Single oral CBD (3, 5, 10 mg/kg)	Haloperidol or CBD caused an increase in time spent in the open arms. This effect was slightly reduced by concomitant CBD/haloperidol administration.	[75]
			Haloperidol reduced motor activity. CBD (5 mg/kg) antagonized hypolocomotion induced by haloperidol.
Mouse	Daily progressive i.p. dose of cocaine (15 to 60 mg/kg) three times a day for 12 days	Single i.p. CBD (10, 20, and 40 mg/kg) given 270 min after the last cocaine administration	All doses of CBD blocked the increase in total distance values induced by cocaine withdrawal.	[76]
Rat	Single i.p. ketamine (30, 60 mg/kg) alone or 10 min after CBD	Single i.p. CBD (10 or 30 mg/kg) alone or 10 min before ketamine	CBD (30 mg/kg) alone decreased motor activity; ketamine (30, 60 mg/kg) alone increased motor activity. CBD did not reverse ketamine-induced short-lasting hyperactivity but prolonged it over time.	[78]
Mouse	Single i.p. S-ketamine (2.5, 3, 5, 10, 30 mg/kg)	I.p. CBD (3, 10, 30 mg/kg) 30 min before S-ketamine	CBD produced antidepressant effects without any influence on motor activity. Higher dose of S-ketamine showed antidepressant effects with increase in motor activity.	[79]

i.p. = intraperitoneal; i.m. = intramuscular.