Table 3.
MIC values for each SrtAI (TC, CUR, QC, BR)-loaded and non-loaded MSN or AMP (PEX, INDO, MASTO) against S. aureus ATCC25923 (MSSA), MRSA ATCC43300, E. coli ATCC25922, and P. aeruginousa ATCC27853 derived from a BMD assay with resazurin colorimetric readout.
| MIC (µg/mL) | ||||
|---|---|---|---|---|
| MSSA | MRSA | E. coli | P. aeruginosa | |
| PEX | 6.25 | 6.25 | 6.25 | 3.13 |
| INDO | 18.8 | 18.8 | 18.8 | 75.0 |
| MASTO | 3.13 | 3.13 | 6.25 | 3.13 |
| MCM-41 | >500 | >500 | >500 | >500 |
| MCM-41-PO3− | >500 | >500 | >500 | >500 |
| TC MCM-41 | 125 | 125 | 500 | 500 |
| CUR MCM-41 | 62.5 | 62.5 | 31.3 | 31.3 |
| QC MCM-41 | 62.5 | 62.5 | 31.3 | 31.3 |
| BR MCM-41 | 125 | 125 | 500 | 500 |
| TC MCM-41-PO3− | 62.5 | 62.5 | 250 | 250 |
| CUR MCM-41-PO3− | 31.3 | 31.3 | 15.6 | 15.6 |
| QC MCM-41-PO3− | 31.3 | 31.3 | 15.6 | 31.3 |
| BR MCM-41-PO3− | 62.5 | 62.5 | 250 | 500 |