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. 2022 Apr 25;10(5):896. doi: 10.3390/microorganisms10050896

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© 2022 by the author.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Model of the interactions among DNA damage response factors which enhance EBV DNA synthesis and viral proteins at RCs. The central kinase of the DDR, ATM, is activated by BGLF4 and BZLF1. Phosphorylated ATM (pATM) activates H2AX (γH2AX), S-phase cyclin-dependent kinases (CDKs), Sp1, and homologous recombinational repair (HRR) enhance viral DNA synthesis. BPLF1 recruits pol η onto newly synthesized viral DNA to mature. Mismatch repair (MMR) factors are also involved in the maturation of viral DNA stored at the BMRF1-core.