Table 1.

Viral proteins accumulate to RCs. “Microscopic analysis” means that the localization to RCs of the viral protein was improved by IFA. “N/A” indicates that the localization to RCs of the viral protein was not improved by IFA but that it was estimated to accumulate in RCs by co-immunoprecipitation analysis with viral proteins recruited to RCs or other functional assays.

Viral Protein	Functions	Roles in RCs	Microscopic Analysis	Refs.
EBNA1	Bridge between chromosome and viral episome	Scaffold for newly synthesized DNA	Yes	[19]
BZLF1	Lytic cycle switch	Activates and modulates DDR L gene transcription	Yes	[19]
Rta	Transcriptional activator	L gene transcription	Yes	[19]
BALF2	ssDNA binding protein	Consists of viral replication forks and synthesizes viral DNA	Yes	[19]
BALF5	DNA polymerase	Consists of viral replication forks and synthesizes viral DNA	Yes	[19]
BMRF1	dsDNA binding protein polymerase processsivity factor	Consists of viral replication forks and synthesizes viral DNA Binds to dsDNA and composes the BMRF1-core Mediates DNA repair L gene transcription	Yes	[19]
BBLF2/3	Helicase–primase complex	Consists of viral replication forks and synthesizes viral DNA	Yes	[19]
BBLF4	Helicase–primase complex	Consists of viral replication forks and synthesizes viral DNA	Yes	[19]
BSLF1	Helicase–primase complex	Consists of viral replication forks and synthesizes viral DNA	Yes	[19]
BKRF3	Uracil DNA glycosylase	Assists in the synthesis of viral DNA	Yes	[38]
BGLF4	Protein kinase	Conducts chromosomal condensationActivates DDR	Yes	[39]
BPLF1	Deubiquitinase	Mediates DNA repair	Yes	[40]
BGLF5	Alkaline nuclease	Viral mRNA export	Yes	[41]
BMLF1	Transcriptional activator	Viral mRNA export	Yes	[41]
BFRF3	Small capsid protein	Consists of viral capsids	Yes	[42]
BVRF1	Minor capsid protein/Capsid packaging protein	Packages viral DNA into capsids	Yes	[42]
BGLF1	Minor capsid protein/Capsid packaging protein	Packages viral DNA into capsids	Yes	[42]
BFLF1	Capsid packaging protein	Packages viral DNA into capsids	Yes	[42]
BDRF1	Minor capsid protein/Capsid packaging protein	Packages viral DNA into capsids	N/A	[43]
BVRF2	Capsid protease	Consists of viral capsids	Yes	[42]
BDLF1	Capsid Triplex 2	Consists of viral capsids	Yes	[42]
BORF1	Capsid Triplex 1	Consists of viral capsids	Yes	[42]
BBRF1	Capsid portal protein	Consists of viral capsids	Yes	[42]
BdRF1	Capsid scaffold protein	Consists of viral capsids and is cleaved	N/A	[44]
BcLF1	Major capsid protein	Consists of viral capsids	N/A	[44]
BDLF3.5	vPIC component	L gene transcription	N/A	[45]
BDLF4	vPIC component	L gene transcription	N/A	[45]
BVLF1	vPIC component	L gene transcription	N/A	[45]
BGLF3	vPIC component	L gene transcription	N/A	[45]
BFRF2	vPIC component	L gene transcription	N/A	[45]
BcRF1	vPIC component	L gene transcription	Yes	[46,47]