Figure 4.

Illustration of the complex chemical environment within living cells and the different water populations. The green/pink molecules depict the bulk-like populations, which are subjected to weak interactions with the biological interfaces and are more abundant in cellular media (they are semi-transparent in the figure for presentation purposes). The red/blue molecules depict the confined-like populations, which are subjected to closer interactions with the biological interfaces and present features of confined dynamics that are not comparable with bulk water.