Table 3.
The cut-off points of FLI stratified by waist circumference and BMI based on the results of liver ultrasound transient elastograpy in NHANES 2017–2018
| Stratification | Total | CAP > 248 | Prevalence (%) | Cut-off points | AUROC | Sensitivity (true positive fraction) (%) | Specificity (true negative fraction) (%) | Positive likelihood ratio | Negative likelihood ratio | Youden index | P value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Total | 4633 | 2721 | 58.73 | > 45.60 | 0.833 (0.822–0.844) | 80.85 (79.3–82.3) | 70.50 (68.4–72.5) | 2.74 | 0.27 | 0.5135 | < 0.0001 |
| Male | 2281 | 1434 | 62.87 | > 48.57 | 0.837 (0.821–0.852) | 81.80 (79.7–83.8) | 69.78 (66.6–72.9) | 2.71 | 0.26 | 0.5157 | < 0.0001 |
| Female | 2352 | 1287 | 54.72 | > 41.93 | 0.829 (0.813–0.844) | 80.34 (78.1–82.5) | 70.89 (68.1–73.6) | 2.76 | 0.28 | 0.5123 | < 0.0001 |
| Stratified by BMI | |||||||||||
| BMI < 18.5 | 76 | 7 | 9.21 | > 5.10 | 0.588 (0.469–0.700) | 71.43 (29.0–96.3) | 68.12 (55.8–78.8) | 2.24 | 0.42 | 0.3954 | 0.5294 |
| 18.5 ≥ BMI < 25.0 | 1191 | 308 | 25.86 | > 20.77 | 0.760 (0.734–0.784) | 63.31 (57.7–68.7) | 78.71 (75.9–81.4) | 2.97 | 0.47 | 0.4200 | < 0.0001 |
| 25.0 ≥ BMI < 30.0 | 1477 | 863 | 58.43 | > 44.73 | 0.732 (0.709–0.755) | 72.54 (69.4–75.5) | 61.56 (57.6–65.4) | 1.89 | 0.45 | 0.3410 | < 0.0001 |
| BMI ≥ 30.0 | 1889 | 1543 | 81.68 | > 86.00 | 0.743 (0.723–0.763) | 68.05 (65.7–70.4) | 67.92 (62.7–72.8) | 2.12 | 0.47 | 0.3597 | < 0.0001 |
| Male | |||||||||||
| BMI < 18.5a | 31 | 4 | 12.90 | ≤ 1.37 | 0.611 (0.420–0.780) | 50.00 (6.8–93.2) | 96.30 (81.0–99.9) | 13.5 | 0.52 | 0.4630 | 0.6189 |
| 18.5 ≥ BMI < 25.0 | 554 | 156 | 28.16 | > 23.26 | 0.757 (0.719–0.792) | 70.51 (62.7–77.5) | 73.62 (69.0–77.9) | 2.67 | 0.40 | 0.4413 | < 0.0001 |
| 25.0 ≥ BMI < 30.0 | 814 | 509 | 62.53 | > 62.09 | 0.727 (0.695–0.757) | 53.05 (48.6–57.5) | 80.98 (76.1–85.2) | 2.79 | 0.58 | 0.3403 | < 0.0001 |
| BMI ≥ 30.0 | 882 | 765 | 86.73 | > 91.35 | 0.725 (0.694–0.754) | 55.95 (52.3–59.5) | 78.63 (70.1–85.7) | 2.62 | 0.56 | 0.3458 | < 0.0001 |
| Female | |||||||||||
| BMI < 18.5 | 45 | 3 | 6.67 | > 4.68 | 0.865 (0.730–0.948) | 100 (2.92–100.0) | 80.95 (65.9–91.4) | 5.25 | 0.00 | 0.8095 | < 0.0001 |
| 18.5 ≥ BMI < 25.0 | 637 | 152 | 23.86 | > 14.33 | 0.768 (0.733–0.800) | 67.76 (59.7–75.1) | 75.05 (71.0–78.8) | 2.72 | 0.43 | 0.4281 | < 0.0001 |
| 25.0 ≥ BMI < 30.0 | 663 | 354 | 53.39 | > 36.67 | 0.731 (0.695–0.764) | 75.14 (70.3–79.6) | 61.49 (55.8–66.9) | 1.95 | 0.40 | 0.3663 | < 0.0001 |
| BMI ≥ 30.0 | 1007 | 778 | 77.26 | > 81.83 | 0.742 (0.714–0.769) | 70.95 (67.6–74.1) | 66.81 (60.3–72.9) | 2.14 | 0.43 | 0.3776 | < 0.0001 |
| Stratified by BMI and WC | |||||||||||
| Male | |||||||||||
| WC < 102 | 1214 | 524 | 43.16 | > 35.60 | 0.780 (0.755–0.803) | 74.43 (70.5–78.1) | 70.00 (66.4–73.4) | 2.48 | 0.37 | 0.4443 | < 0.0001 |
| BMI < 18.5a | 31 | 4 | 12.90 | ≤ 1.37 | 0.608 (0.426–0.771) | 50.00 (6.8–93.2) | 96.67 (82.8–99.9) | 15.0 | 0.52 | 0.4667 | 0.6314 |
| 18.5 ≥ BMI < 25.0 | 552 | 154 | 27.90 | > 23.26 | 0.754 (0.716–0.789) | 70.13 (62.2–77.2) | 73.62 (69.0–77.9) | 2.66 | 0.41 | 0.4375 | < 0.0001 |
| 25.0 ≥ BMI < 30.0 | 572 | 323 | 56.47 | > 45.60 | 0.708 (0.669–0.745) | 70.90 (65.6–75.8) | 59.84 (53.5–66.0) | 1.77 | 0.49 | 0.3074 | < 0.0001 |
| BMI ≥ 30.0 | 59 | 43 | 72.88 | > 68.03 | 0.686 (0.552–0.801) | 67.44 (51.5–80.9) | 68.75 (41.3–89.0) | 2.16 | 0.47 | 0.3619 | 0.0223 |
| WC ≥ 102 | 1067 | 910 | 85.29 | > 85.04 | 0.718 (0.690–0.745) | 66.37 (63.2–69.4) | 66.24 (58.3–73.6) | 1.97 | 0.51 | 0.3262 | < 0.0001 |
| BMI < 18.5b | 0 | ||||||||||
| 18.5 ≤ BMI < 25.0b | 2 | 0 | |||||||||
| 25.0 ≤ BMI < 30.0 | 242 | 186 | 76.86 | > 63.30 | 0.679 (0.617–0.738) | 69.89 (62.8–76.4) | 60.71 (46.8–73.5) | 1.78 | 0.5 | 0.3061 | < 0.0001 |
| BMI ≥ 30.0 | 823 | 722 | 87.73 | > 91.35 | 0.718 (0.686–0.749) | 58.86 (55.2–62.5) | 75.25 (65.7–83.3) | 2.38 | 0.55 | 0.3411 | < 0.0001 |
| Female | |||||||||||
| WC < 88 | 721 | 157 | 21.78 | > 14.29 | 0.774 (0.742–0.804) | 67.52 (59.6–74.8) | 77.48 (73.8–80.9) | 3.00 | 0.42 | 0.4500 | < 0.0001 |
| BMI < 18.5 | 45 | 3 | 6.67 | > 4.68 | 0.865 (0.730–0.948) | 100.00 (29.2–100) | 80.95 (65.9–91.4) | 5.25 | 0.00 | 0.8095 | < 0.0001 |
| 18.5 ≤ BMI < 25.0 | 526 | 99 | 18.82 | > 11.58 | 0.751 (0.711–0.787) | 65.66 (55.4–74.9) | 74.71 (70.3–78.8) | 2.6 | 0.46 | 0.4036 | < 0.0001 |
| 25.0 ≤ BMI < 30.0 | 146 | 54 | 36.99 | > 23.48 | 0.736 (0.657–0.805) | 68.52 (54.4–80.5) | 70.65 (60.2–79.7) | 2.33 | 0.45 | 0.3917 | < 0.0001 |
| BMI ≥ 30.0b | 4 | 1 | 25.00 | ||||||||
| WC ≥ 88 | 1631 | 1130 | 69.28 | > 75.28 | 0.748 (0.726–0.769) | 58.23 (55.3–61.1) | 78.64 (74.8–82.2) | 2.73 | 0.53 | 0.3687 | < 0.0001 |
| BMI < 18.5b | 0 | ||||||||||
| 18.5 ≤ BMI < 25.0 | 111 | 53 | 47.75 | > 30.65 | 0.629 (0.532–0.719) | 58.49 (44.1–71.9) | 68.97 (55.5–80.5) | 1.88 | 0.6 | 0.2746 | 0.0171 |
| 25.0 ≤ BMI < 30.0 | 517 | 300 | 58.03 | > 36.67 | 0.706 (0.665–0.745) | 82.33 (77.5–86.5) | 49.77 (42.9–56.6) | 1.64 | 0.35 | 0.3210 | < 0.0001 |
| BMI ≥ 30.0 | 1003 | 777 | 77.47 | > 81.83 | 0.740 (0.711–0.767) | 71.04 (67.7–74.2) | 66.37 (59.8–72.5) | 2.11 | 0.44 | 0.3741 | < 0.0001 |
CAP controlled attenuation parameter, AUROC area under the receiver operating characteristic curves, BMI body mass index, WC waist circumference
aThe calculated AUROC < 0.5, which can not meet the requirements of diagnostic test
bThe optimal cut-off point of FLI could not be obtained due to insufficient data