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. 2022 May 28;15:21. doi: 10.1186/s13072-022-00454-7

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Maximum Likelihood trees of histone doublets. The trees are unrooted, but drawn as if rooted on archaeal doublets. Archaea (blue); eukaryotes (orange); Marseilleviridae (green); insect iridoviruses (red). Alignments were made with EMBL-EBI Muscle software and manually trimmed to remove the N-terminal tails, leaving the histone fold domains, the αN helix and docking domain of H2A, and the αC helix of H2B. The alignments were used to make maximum likelihood trees with IQ Tree [129] and viewed and annotated with Dendroscope 3.0 [130]. Numbers in parentheses are SH-aLRT support (%)/Ultrafast Bootstrap support (%)