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. Author manuscript; available in PMC: 2022 May 28.
Published in final edited form as: Immunol Rev. 2019 Nov 12;292(1):90–101. doi: 10.1111/imr.12821

Figure 1. Central B cell tolerance is compromised in patients with autoimmune disease and healthy donors carrying the 1858T PTPN22 polymorphism.

Figure 1.

Frequencies of polyreactive new emigrant/transitional B cells in patients with type 1 diabetes (T1D), rheumatoid arthritis (RA), pediatric systemic lupus erythematosus (SLE), Sjögren’s syndrome (SjS), myasthenia gravis (MG), neuromyelitis optica spectrum disease (NMOSD), multiple sclerosis (MS) and healthy donors (HD) with either heterozygous (C/T) or homozygous (T/T) PTPN22 polymorphism were compared to the frequencies derived from a cohort of healthy donors who did not carry the 1858T PTPN22 risk allele. Proportions of polyreactive antibodies expressed by new emigrant/transitional B cells were plotted for each subject group along with the mean and standard deviation for each subject group. Statistical differences are shown when significant (****, p < 0.0001; ***, p < or = to 0.001; **, p < or = to 0.01).