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. Author manuscript; available in PMC: 2022 May 28.
Published in final edited form as: Immunol Rev. 2019 Nov 12;292(1):90–101. doi: 10.1111/imr.12821

Figure 4. Variable region family usage is skewed in the naïve BCR repertoire of patients with myasthenia gravis who suffer from impaired early B cell tolerance checkpoints.

Figure 4.

Antibody heavy chain variable region family usage for the naïve (IgM) B cell compartment. The analysis was performed with 114,296 unique sequences collected from four HDs, three AChR autoantibody positive MG patients (AChR), and three MuSK autoantibody positive MG patients (MuSK). Usage is shown as a frequency of the total unique IGHV sequences (y-axis) for each subject (symbols). Horizontal bars indicate the mean abundance over all subjects of a given status and vertical shading indicates +/− 1 SD about the mean. Data previously reported 81.