Table 1.

In vitro AChE inhibitory activity of compounds 10a–10s and 13a–13p.

Compd.	X	R	IC50 a (nM)	Compd.	X	R	IC50 a (nM)
			AChE				AChE
10a	Me	H	1.61 ± 0.02	10s	Me	4-CF3	325.94 ± 9.01
10b	Me	2-F	3.32 ± 0.21	13a	NH2	H	8.63 ± 0.06
10c	Me	3-F	4.03 ± 0.23	13b	NH2	2-F	3.54 ± 0.05
10d	Me	4-F	7.69 ± 0.35	13c	NH2	3-F	6.02 ± 0.08
10e	Me	2-Cl	5.86 ± 0.86	13d	NH2	4-F	8.25 ± 0.13
10f	Me	3-Cl	10.26 ± 1.08	13e	NH2	2-Cl	17.58 ± 0.30
10g	Me	4-Cl	67.32 ± 2.68	13f	NH2	3-Cl	26.74 ± 0.28
10h	Me	2-Br	6.22 ± 0.05	13g	NH2	4-Cl	188.34 ± 4.78
10i	Me	3-Br	10.98 ± 0.82	13h	NH2	2-Br	21.71 ± 0.32
10j	Me	4-Br	75.72 ± 3.18	13i	NH2	3-Br	38.14 ± 0.92
10k	Me	2-Me	4.80 ± 0.26	13j	NH2	4-Br	421.76 ± 5.92
10l	Me	3-Me	6.61 ± 0.81	13k	NH2	2-Me	12.14 ± 0.90
10m	Me	4-Me	54.10 ± 3.22	13l	NH2	3-Me	16.26 ± 0.12
10n	Me	2-NO2	13.58 ± 0.72	13m	NH2	4-Me	42.47 ± 0.25
10o	Me	3-NO2	22.45 ± 1.25	13n	NH2	2-CF3	30.71 ± 0.71
10p	Me	4-NO2	128.86 ± 2.68	13o	NH2	3-CF3	43.05 ± 0.44
10q	Me	2-CF3	18.87 ± 1.16	13p	NH2	4-CF3	441.18 ± 7.82
10r	Me	3-CF3	25.32 ± 2.20	Donepezil			12.06 ± 0.01

^a All values are expressed as mean ± SEM from three independent experiments.