Table 1.
IC50 for Taxol and cisplatin, and combination index (CI) for the combination of both drugs in SKOV3 and CAOV3 cells. CI < 1 indicates synergistic effect, CI = 1 indicates additive effects and CI > 1 indicates antagonistic effect.
| Cell Line | Drug | IC50 [nM] | Combination Index (CI) [nM] | ||||
|---|---|---|---|---|---|---|---|
| Control | Sequence 1 | Sequence 2 | Control | Sequence 1 | Sequence 2 | ||
| SKOV3 | Taxol | 2.909 | 1.679 | 0.4900 | - | - | - |
| Cisplatin | 2.270 | 2.887 | 1.355 | - | - | - | |
| Taxol/Cisplatin | - | - | - | 0.930 | 18.198 | <0.001 | |
| CAOV3 | Taxol | 1.952 | 1.947 | 1.985 | - | - | - |
| Cisplatin | 1.222 | 1.304 | 1.360 | - | - | ||
| Taxol/Cisplatin | - | - | - | 13.013 | 10.649 | 12.774 | |