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. 2022 May 6;14(5):1002. doi: 10.3390/pharmaceutics14051002

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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In vitro exosome targeting to U87 cells. (a,c) DiI-U87 exo showed higher fluorescence intensity than DiI-A549 exo in U87 cells. *** p < 0.001 vs. non-treated control, ### p < 0.001 vs. DiI-A549-Selu exo. n = 3. (b,d) DiI-U87-Selu exo showed higher fluorescence intensity than DiI-A549-Selu exo in U87 cells. *** p < 0.001 vs. control, ### p < 0.001 vs. DiI-A549-Selu exo. n = 3. (e,f) In the 96-well plate, the quantitative uptake of DiI-U87 exo and DiI-U87-Selu exo were higher than DiI-A549 exo and DiI-A549-Selu exo. ** p < 0.01, *** p < 0.001 vs. non-treated control; # p < 0.05, ### p < 0.001 vs. DiI-A549-Selu exo. n = 8. Data are represented as mean ± SD.