Table 3.
Concentrations inducing a 10% loss of viability (10% Effective Dose, or ED10, including a 90% Confidence Interval (CI)), calculated by dose–response modelling. For nanostars, an ED10 could not be calculated. The data of the three replicate experiments were analysed together.
Nanospheres | Nanorods | |||
---|---|---|---|---|
ED10 (µg/mL) | 90% CI | ED10 (µg/mL) | 90% CI | |
Wildtype | 9.5 | 2.4–18.0 | 34.1 | 20.4–51.8 |
ASC-def | 12 | 6.8–17.1 | 169 | 97.2–299 |
NLRP3-def | 17.7 | 10.7–18.5 | 166 | 47.7–242 |